Sulfonylation of Propargyl Alcohols with Sulfinamides for the Synthesis of Allenyl Sulfones.
Fei-Fei ZouZhen LuoYu-Ting YangXin ZhuangChuan-Ming HongZheng-Qiang LiuWan-Fang LiQing-Hua LiTang-Lin LiuPublished in: The Journal of organic chemistry (2022)
A regio- and chemoselective sulfonylation of propargyl alcohols with sulfinamides in 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) was developed. It provided straightforward and mild access to multi-substituted allenyl sulfones by using sulfinamides as the sulfonyl sources. This transformation was promoted by HFIP and did not require any catalysts or oxidants, which allowed for the successful conversion of various tertiary and secondary propargyl alcohols into allenyl sulfones in high yields.
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