Cp*Co(III)-Catalyzed Annulation of Carboxylic Acids with Alkynes.
Rajib MandalBasker SundararajuPublished in: Organic letters (2017)
A new procedure for oxidative coupling of aromatic and acrylic acids with alkynes has been developed using abundant, nontoxic, and air stable Cp*Co(III) catalyst. The coupling involves initial cyclometalation via weak chelation-assisted C-H bond activation followed by alkyne coordination, insertion, and reductive elimination leading to diverse isocoumarins (α-pyranones) in good yields under mild conditions.