DoE-assisted development and validation of a stability-indicating HPLC-DAD method for simultaneous determination of five cannabinoids in Cannabis sativa L. based on analytical quality by design (AQbD) concept.
Maíra Ribeiro de SouzaMariana KoetzRenata Pereira LimbergerAmélia Teresinha HenriquesPublished in: Phytochemical analysis : PCA (2022)
The application of an AQbD-driven approach allowed for a better understanding of the effects of the ensemble of CMV on the analyte's behaviour, enabling the definition of appropriate conditions to ensure consistent achievement of the intended method's performance.
Keyphrases
- simultaneous determination
- liquid chromatography tandem mass spectrometry
- liquid chromatography
- tandem mass spectrometry
- high performance liquid chromatography
- ultra high performance liquid chromatography
- solid phase extraction
- mass spectrometry
- ms ms
- high resolution mass spectrometry
- convolutional neural network
- gas chromatography
- neural network