Dose Escalation with Simultaneous Integrated Boost (SIB) Using Volumetric Modulated Arc Therapy (VMAT) in Rectal Cancer.

Abdullah A AlsuhaibaniAhmed ElashwahRana MahmoodAlaa AbduljabbarSamar AlhomoudLuai AshariShouki BazarbashiAli AljubranAhmed AlzahraniMuhamed MohiuddinHadeel AlmaneaHussah AlhussainiNasser AlSanea

Published in: Journal of gastrointestinal cancer (2018)

Dose escalation with SIB-VMAT as NACRT for rectal cancer is feasible. Moreover, it can increase the rate of pathological complete response with a favorable toxicity profile. Clinical benefit of this approach needs to be validated in a larger cohort of patients with longer follow-up.

Keyphrases

rectal cancer
locally advanced
open label
squamous cell carcinoma
radiation therapy
mesenchymal stem cells
study protocol
oxide nanoparticles