Recent progress in the development of metal complexes as β-amyloid imaging probes in the brain.
Kaihua ChenMeng-Chao CuiPublished in: MedChemComm (2017)
In this review, we have focused on the recent progress in metal complexes that are able to bind to β-amyloid (Aβ) species. We have discussed various radioactive complexes of 99mTc, 68Ga, 64Cu, 89Zr, and 111In, which were designed as Aβ imaging agents for positron emission tomography (PET) and single photon emission computed tomography (SPECT) imaging, non-radioactive Re and Ru complexes as Aβ sensors using luminescence methods, and Gd3+ complexes as contrast agents for magnetic resonance imaging (MRI).
Keyphrases
- computed tomography
- positron emission tomography
- magnetic resonance imaging
- pet ct
- contrast enhanced
- high resolution
- pet imaging
- fluorescence imaging
- magnetic resonance
- mass spectrometry
- dual energy
- blood brain barrier
- single molecule
- metal organic framework
- living cells
- energy transfer
- functional connectivity
- brain injury