Effect of Stem Cell Injections on Osteoarthritis-related Structural Outcomes: A Systematic Review.
Jennifer GongJessica FairleyFlavia M CicuttiniSultana Monira HussainRakhi VashishthaLouisa ChouAnita E WlukaYuanyuan WangPublished in: The Journal of rheumatology (2020)
Our systematic review of early-phase clinical trials demonstrated consistent evidence of a beneficial effect of intraarticular MSC injections on articular cartilage and subchondral bone. Due to the heterogeneity of MSCs, modest sample sizes, methodological limitations, and potential for publication bias, further work is needed before this therapy is recommended in the management of OA.
Keyphrases
- systematic review
- stem cells
- clinical trial
- platelet rich plasma
- knee osteoarthritis
- ultrasound guided
- meta analyses
- mesenchymal stem cells
- rheumatoid arthritis
- bone mineral density
- single cell
- umbilical cord
- human health
- soft tissue
- type diabetes
- bone loss
- skeletal muscle
- risk assessment
- insulin resistance
- climate change
- phase iii
- weight loss
- adipose tissue
- body composition