Activated Protein C Strengthens Cardiac Tolerance to Ischemic Insults in Aging.

Di RenJulia FedorovaKayla DavittTran Ngoc Van LeJohn H GriffinPatricia C LiawCharles T EsmonAlireza R Rezaie Ji Li

Published in: Circulation research (2021)

I/R stress causes shedding of the membrane EPCR in the heart, and administration of APC prevents I/R-induced cardiac EPCR shedding that is critical for limiting cardiac damage in aging.

Keyphrases

left ventricular
heart failure
oxidative stress
high glucose
diabetic rats
protein protein
brain injury
subarachnoid hemorrhage