Phosphorylation and Stabilization of PIN1 by JNK Promote Intrahepatic Cholangiocarcinoma Growth.

Alessio LeporePui Man ChoyNathan C W LeeMaria Annunziata CarellaRosy FavicchioMarco A Briones-OrtaShannon S GlaserGianfranco AlpiniClive D'SantosReuben M ToozeMihaela LorgerWing-Kin SynAthanasios Papakyriakou Georgios Giamas Concetta Bubici Salvatore Papa

Published in: Hepatology (Baltimore, Md.) (2021)

Our findings implicate the JNK-PIN1 regulatory axis as a functionally important determinant for ICC growth, and provide a rationale for therapeutic targeting of JNK activation through PIN1 inhibition.

Keyphrases

signaling pathway
cell death
induced apoptosis
clinical trial
transcription factor
endoplasmic reticulum stress
cancer therapy