Circulating miRNA Signatures Associated with Insulin Resistance in Adolescents with Obesity.

Haixia LinEmir TasElisabet BørsheimKelly E Mercer

Published in: Diabetes, metabolic syndrome and obesity : targets and therapy (2020)

Specific signatures of circulating miRNAs reflected metabolic phenotypes and predicted the presence of IR in adolescents with obesity, suggesting that miRNA indicators may identify obesity-associated complications in childhood. Further studies will be needed to understand cause versus effect and the mechanisms by which IR status links to changes in blood miRNA profiles.

Keyphrases

insulin resistance
metabolic syndrome
weight loss
high fat diet induced
young adults
type diabetes
weight gain
physical activity
genome wide
risk factors
case control