Lower blood levels of isavuconazole in critically ill patients compared with other populations: possible need for therapeutic drug monitoring.

Malgorzata MikulskaMonica MelchioAlessio SignoriNadir UllahFranca MiletichChiara SepulcriAlessandro LimongelliDaniele Roberto GiacobbeElisa BallettoChiara RussoLaura MagnascoAntonio VenaCarmen Di GraziaAnna Maria RaiolaFederica PortunatoChiara DentoneDenise BattagliniLorenzo BallFabio Silvio TacconeEmanuele AngelucciIole BrunettiMatteo Bassetti

Published in: The Journal of antimicrobial chemotherapy (2024)

ICU patients had significantly lower isavuconazole blood levels compared to non-ICU population. The TDM of isavuconazole for efficacy should be performed in ICU.

Keyphrases

intensive care unit
mechanical ventilation
ejection fraction
newly diagnosed
prognostic factors