Germline genetic variants in men with prostate cancer and one or more additional cancers.

Patrick G PiliéAnna M JohnsonKristen L HansonMegan E DaynoAshley L KapronElena M StoffelKathleen A Cooney

Published in: Cancer (2017)

Men with prostate cancer and at least 1 additional primary cancer are enriched for harboring a germline deleterious mutation in a cancer-predisposing gene that may impact cancer prognosis and treatment, but the majority do not meet current criteria for clinical genetic testing. Cancer 2017;123:3925-32. © 2017 American Cancer Society.

Keyphrases

prostate cancer
papillary thyroid
squamous cell
childhood cancer
gene expression
dna methylation
genome wide
dna damage
oxidative stress
copy number