Non-canonical Wnt signaling triggered by WNT2B drives adrenal aldosterone production.

Kleiton Silva BorgesDonald W LittleTaciani de Almeida MagalhãesClaudio RibeiroTyphanie DumontetChris LapenseeKaitlin J BashamAishwarya SethSvetlana AzovaNick A GuagliardoPaula Q BarrettMesut BerberAmy E O'ConnellAdina F TurcuAntonio Marcondes LerarioDipika R MohanWilliam RaineyDiana L CarloneJoel N HirschhornAdrian SalicDavid T BreaultGary D Hammer

Published in: bioRxiv : the preprint server for biology (2024)

knock-out mice have hyperreninemic hypoaldosteronism WNT2B activates non-canonical Wnt/planar cell polarity signalingWNT2B deficiency causes a new form of familial hyperreninemic hypoaldosteronism.

Keyphrases

cell proliferation
stem cells
single cell
cell therapy
early onset
angiotensin ii