RhoA/ROCK2 signalling is enhanced by PDGF-AA in fibro-adipogenic progenitor cells: implications for Duchenne muscular dystrophy.

Esther Fernández-SimónXavier Suárez-CalvetAna Carrasco-RozasPatricia Piñol-JuradoSusana López-FernándezGemma PonsJoan Josep Bech SerraCarolina de la TorreNoemí de LunaEduard GallardoJordi Díaz-Manera

Published in: Journal of cachexia, sarcopenia and muscle (2022)

Our results suggest that PDGF-AA promotes the activation of RhoA pathway in FAPs from DMD patients. This pathway could be involved in FAPs activation promoting its proliferation, migration, and actin reorganization, which represents the beginning of the fibrotic process. The inhibition of RhoA pathway could be considered as a potential therapeutic target for muscle fibrosis in patients with muscular dystrophies.

Keyphrases

duchenne muscular dystrophy
end stage renal disease
ejection fraction
newly diagnosed
vascular smooth muscle cells
prognostic factors
muscular dystrophy
risk assessment
patient reported outcomes
resistance training
patient reported