Helicobacter pylori-induced REDD1 modulates Th17 cell responses that contribute to gastritis.

Zong-Bao YanJin-Yu ZhangYi-Pin LvWen-Qing TianZhi-Guo ShanFang-Yuan MaoYu-Gang LiuWan-Yan ChenPan WangYun YangPing ChengLiu-Sheng PengYa-Ling LiaoGeng-Yu YueXiao-Lin XuYong-Liang ZhaoMu-Han LüYuan Zhuang

Published in: Clinical science (London, England : 1979) (2021)

The present study identifies a novel regulatory network involving REDD1, which collectively exert a pro-inflammatory effect within gastric microenvironment. Efforts to inhibit this REDD1-dependent pathway may prove valuable strategies in treating of H. pylori-associated gastritis.

Keyphrases

helicobacter pylori
helicobacter pylori infection
stem cells
high glucose
single cell
cell therapy
diabetic rats
genome wide
transcription factor
drug induced
quality improvement
gene expression
endothelial cells
oxidative stress
bone marrow
dna methylation