Amphibian-derived peptide homodimer OA-GL17d promotes skin wound regeneration through the miR-663a/TGF-β1/Smad axis.

Yue ZhangYing WangLin ZengYixiang LiuHuiling SunShanshan LiSiyu WangLongjun ShuNaixin LiuSaige YinJunsong WangDan NiYutong WuYing YangLi HeBuliang MengMeifeng Yang

Published in: Burns & trauma (2022)

Our results suggest that OA-GL17d is a new peptide drug candidate for skin wound repair. This study emphasizes the importance of exogenous peptides as molecular probes for exploring competing endogenous RNA mechanisms and indicates that miR-663a may be an effective target for promoting skin repair.

Keyphrases

wound healing
cell proliferation
soft tissue
long non coding rna
transforming growth factor
long noncoding rna
stem cells
knee osteoarthritis
epithelial mesenchymal transition
single molecule
surgical site infection