Vasoactive intestinal peptide-induced tolerogenic dendritic cells attenuated arthritis in experimental collagen-induced arthritic mice.

Huaxiang WuJingfang ShenLei LiuXiaoyong LuJing Xue

Published in: International journal of rheumatic diseases (2019)

VIP-DC showed reduced immunogenicity and enhanced anti-inflammatory cytokine production. Both VIP-DC and Bay-DC could ameliorate arthritis in CIA mice clinically. VIP-DC were not inferior to Bay 11-7082-induced tolDC but may exert a better preventive effect on bone destruction.

Keyphrases

dendritic cells
high glucose
diabetic rats
regulatory t cells
immune response
rheumatoid arthritis
anti inflammatory
drug induced
oxidative stress
endothelial cells
metabolic syndrome
high fat diet induced
type diabetes
skeletal muscle
body composition
postmenopausal women
bone loss
stress induced