Inclusion body myositis in patients with spinocerebellar ataxia types 3 and 6.

Anke RietveldJudith van GaalenChristiaan Saris Kees OkkersenBenno KüstersBart van de WarrenburgBaziel van EngelenSabrina SacconiJoost Raaphorst

Published in: Journal of neurology, neurosurgery, and psychiatry (2020)

We report on five patients with concomitant SCA and IBM. Our cases may merely illustrate coincidental co-occurrence of IBM and SCA-3/SCA-6. However, the presence of SCA mutations could predispose to the development of IBM in some SCA patients, or, the presence of toxic aggregates and malfunctioning of cellular quality control processes in both diseases could indicate a convergence of disease mechanisms.

Keyphrases

quality control
end stage renal disease
ejection fraction
chronic kidney disease
prognostic factors
peritoneal dialysis
interstitial lung disease
systemic sclerosis
myasthenia gravis