Single-cell molecular profiling using ex vivo functional readouts fuels precision oncology in glioblastoma.

Dena PanovskaPouya NazariBasiel ColePieter-Jan CreemersMarleen DerweduweLien SolieSofie Van GassenAnnelies ClaeysTatjana VerbekeElizabeth F CohenMichael Y TolstorukovYvan SaeysDavid Van der PlankenFrancesca M BosisioEric PutSven BampsPaul M ClementMichiel VerfaillieRaf SciotKeith L LigonSteven De VleeschouwerAsier AntoranzFrederik De Smet

Published in: Cellular and molecular life sciences : CMLS (2023)

PROSPERO provides a precise way to evaluate therapy efficacy by measuring molecular drug responses using specific biomarker changes in freshly resected brain tumor samples, in addition to providing key functional insights in cellular behavior, which may ultimately complement standard, clinical biomarker evaluations.

Keyphrases

single cell
rna seq
single molecule
lymph node
palliative care
high throughput
stem cells
emergency department
adverse drug
prognostic factors