Spatial transcriptomics reveals heterogeneity of histological subtypes between lepidic and acinar lung adenocarcinoma.

Linshan XieHui KongJinjie YuMengting SunShaohua LuYong ZhangJie HuFang DuQiuyu LianHongyi XinJian ZhouXiangdong WangCharles A PowellFred R HirschChunxue BaiYuanlin SongJun Yin Da-Wei Yang

Published in: Clinical and translational medicine (2024)

These findings illustrate that assessing patient histological subtypes at the single-cell level is feasible. Additionally, tumour endothelial cells that express PD-L1 in stage IA LUAD suppress immune-responsive CD8+ T cells.

Keyphrases

single cell
rna seq
endothelial cells
high throughput
case report
cancer therapy
drug delivery