A prognostic hypoxia gene signature with low heterogeneity within the dominant tumour lesion in prostate cancer patients.

Unn Beate SalbergVilde Eide SkingenChristina Sæten FjeldboTord HomplandHarald Bull RagnumLjiljana VlatkovicKnut Håkon HoleTherese SeierstadHeidi Lyng

Published in: British journal of cancer (2022)

Our signature from the index lesion reflects tumour hypoxia and predicts prognosis in prostate cancer, independent of intra-tumour heterogeneity in pimonidazole-defined hypoxia.

Keyphrases

prostate cancer
radical prostatectomy
end stage renal disease
endothelial cells
single cell
newly diagnosed
ejection fraction
chronic kidney disease
prognostic factors
genome wide
patient reported outcomes
genome wide identification