Swinhoeic acid from Potentilla fragarioides ameliorates high glucose-induced oxidative stress and accumulation of ECM in mesangial cells via Keap1-dependent activation of Nrf2.

Huankai YaoMin KongDan DuFengwei AiJindong LiYan Li

Published in: Redox report : communications in free radical research (2022)

Swinhoeic acid ameliorates oxidative stress and accumulation of ECM resulting from high glucose in mesangial cells via activating Nrf2 in Keap1-dependent manner.

Keyphrases

high glucose
endothelial cells
oxidative stress
induced apoptosis
cell cycle arrest
signaling pathway
endoplasmic reticulum stress
mouse model
cell death
dna damage
nitric oxide
hydrogen peroxide
heat shock protein