Decellularized Graft for Repairing Severe Peripheral Nerve Injuries in Sheep.

Estefanía ContrerasSara TraserraSara BolívarNúria Nieto-NicolauJessica JaramilloJoaquim ForésEduard Jose-CunillerasXavier MollFélix GarcíaIgnacio Delgado-MartínezOscar FariñasPatrícia López-ChicónAnna VilarrodonaEsther UdinaXavier Navarro

Published in: Neurosurgery (2023)

The decellularized graft assayed supported effective axonal regeneration when used to repair a 5-cm long gap in the sheep. As expected, a delay in functional recovery was observed compared with the AG because of the lack of Schwann cells.

Keyphrases

peripheral nerve
extracellular matrix
induced apoptosis
stem cells
cell cycle arrest
tissue engineering
spinal cord injury
quantum dots
signaling pathway
oxidative stress
highly efficient
drug induced
optical coherence tomography