Long-Acting, Potent Delivery of Combination Antiretroviral Therapy.
Anna Halling Folkmar AndersenCamilla F RiberKaja ZuwalaMartin TolstrupFrederik Dagnæs-HansenPaul W DentonAlexander N ZelikinPublished in: ACS macro letters (2018)
Antiretroviral therapy (ART) has revolutionized HIV treatment, yet grand challenges remain: (i) short blood and body residence time of the antiviral drugs, (ii) relative poor antiretroviral drug penetrance into key tissue reservoirs of viral infection, namely, the spleen and lymph nodes, and (iii) obstacles in different pharmacokinetics of the necessary combination drugs. We present a novel drug delivery approach that simultaneously overcomes these limitations. We designed albumin-polymer-drug conjugates where albumin ensures long body residence time as well as lymphatic accumulation of the conjugate. The polymer enabled the delivery of combinations of drugs in precise ratios affording potency superior to the individual antiretroviral drugs and strong protection from HIV infection in primary human T cells.
Keyphrases
- antiretroviral therapy
- hiv infected
- hiv positive
- human immunodeficiency virus
- hiv infected patients
- hiv aids
- lymph node
- drug delivery
- drug induced
- cancer therapy
- endothelial cells
- hepatitis c virus
- men who have sex with men
- adverse drug
- emergency department
- electronic health record
- induced pluripotent stem cells
- sentinel lymph node