A phenome-wide bidirectional Mendelian randomization analysis of atrial fibrillation.
Qin WangTom G RichardsonEleanor C M SandersonMatthew J TudballMika Ala-KorpelaGeorge Davey SmithMichael V HolmesPublished in: International journal of epidemiology (2022)
Our results suggest body mass index, height, systolic blood pressure and genetic liability to coronary artery disease are independent causal risk factors for AF. Several proteins, including DUSP13, IL-6R and TNFSF12, may have therapeutic potential for AF.
Keyphrases
- atrial fibrillation
- body mass index
- blood pressure
- coronary artery disease
- percutaneous coronary intervention
- heart failure
- oral anticoagulants
- catheter ablation
- left atrial
- hypertensive patients
- left atrial appendage
- direct oral anticoagulants
- weight gain
- heart rate
- physical activity
- coronary artery bypass grafting
- cardiovascular events
- genome wide
- copy number
- dna methylation
- transcatheter aortic valve replacement
- insulin resistance