Mitochondrial Oxidative Phosphorylation Function and Mitophagy in Ischaemic/Reperfused Hearts from Control and High-Fat Diet Rats: Effects of Long-Term Melatonin Treatment.

Karthik DhanabalanSibonginkosi MzezewaBarbara HuisamenAmanda Lochner

Published in: Cardiovascular drugs and therapy (2021)

The results suggest that I/R (i) affects mitochondria from control and HFSD hearts similarly and (ii) melatonin-induced cardioprotection is not associated with reversal of mitochondrial dysfunction or changes in the PINK1/Parkin pathway.

Keyphrases

high fat diet
insulin resistance
adipose tissue
oxidative stress
high glucose
diabetic rats
cell death
reactive oxygen species
metabolic syndrome
endothelial cells
endoplasmic reticulum
skeletal muscle
protein kinase