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Assessment of Plasmodium falciparum anti-malarial drug resistance markers in pfcrt and pfmdr1 genes in isolates from Honduras and Nicaragua, 2018-2021.

Gustavo Adolfo Fontecha SandovalAlejandra PintoOsman ArchagaSergio BetancourthLenin EscoberJessica HenríquezHugo O ValdiviaAlberto MontoyaRosa Elena Mejía
Published in: Malaria journal (2021)
The increase in falciparum malaria cases in Nicaragua and Honduras cannot be attributed to the emergence of chloroquine-resistant mutants. Other possibilities should be investigated further. This is the first study to report the genotype of pfmdr1 for five loci of interest in Central America.
Keyphrases
  • plasmodium falciparum
  • genome wide
  • dna methylation
  • atomic force microscopy
  • transcription factor
  • bioinformatics analysis