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Endothelial cell regulation of systemic haemodynamics and metabolism acts through the HIF transcription factors.

Simon LambdenAndrew S CowburnDavid MaciasTessa A C GarrudBernardo J KrauseDino A GiussaniCharlotte SummersRandall S Johnson
Published in: Intensive care medicine experimental (2021)
These data show that deficiency of HIF-1α in the systemic or pulmonary endothelium is associated with increased systemic blood pressure and metabolic rate, a pattern that persists in both normoxic conditions and in response to acute stress with potential implications for our understanding of the pathophysiology of vascular dysfunction in acute and chronic disease.
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