Endothelial cell regulation of systemic haemodynamics and metabolism acts through the HIF transcription factors.
Simon LambdenAndrew S CowburnDavid MaciasTessa A C GarrudBernardo J KrauseDino A GiussaniCharlotte SummersRandall S JohnsonPublished in: Intensive care medicine experimental (2021)
These data show that deficiency of HIF-1α in the systemic or pulmonary endothelium is associated with increased systemic blood pressure and metabolic rate, a pattern that persists in both normoxic conditions and in response to acute stress with potential implications for our understanding of the pathophysiology of vascular dysfunction in acute and chronic disease.
Keyphrases
- liver failure
- endothelial cells
- drug induced
- blood pressure
- respiratory failure
- transcription factor
- aortic dissection
- nitric oxide
- pulmonary hypertension
- oxidative stress
- hepatitis b virus
- electronic health record
- metabolic syndrome
- intensive care unit
- blood glucose
- mechanical ventilation
- extracorporeal membrane oxygenation
- weight loss
- vascular endothelial growth factor
- data analysis
- genome wide identification