Locally Directed Recombinant Adeno- Associated Virus-Mediated IGF-1 Gene Therapy Enhances Osteochondral Repair and Counteracts Early Osteoarthritis In Vivo.

Carolin PeiferTamás OláhJagadeesh K VenkatesanLars K H GoebelPatrick OrthGertrud SchmittDavid ZurakowskiMichael D MengerMatthias W LaschkeMagali CucchiariniHenning Madry

Published in: The American journal of sports medicine (2024)

IGF-1 gene therapy may be beneficial in repair of focal osteochondral defects and prevention of perifocal OA.

Keyphrases

gene therapy
knee osteoarthritis
pi k akt
platelet rich plasma
binding protein
rheumatoid arthritis
growth hormone
signaling pathway
cell proliferation