Lower functional hippocampal connectivity in healthy adults is jointly associated with higher levels of leptin and insulin resistance.

Shalaila S Haas Alison Myoraku Kathleen T Watson Thalia K Robakis Sophia Frangou Fahim AbbasiNatalie Rasgon

Published in: European psychiatry : the journal of the Association of European Psychiatrists (2022)

We identified two clusters of individuals differentiated by abnormalities in insulin resistance, leptin levels, and hippocampal connectivity, with one of the clusters showing greater deviance. These findings support the link between metabolic dysregulation and hippocampal function even in nonclinical samples.

Keyphrases

insulin resistance
resting state
cerebral ischemia
adipose tissue
high fat diet
metabolic syndrome
type diabetes
polycystic ovary syndrome
temporal lobe epilepsy
functional connectivity
white matter
skeletal muscle
high fat diet induced
glycemic control
multiple sclerosis