Increased hydrogen peroxide impairs angiotensin II contractions of afferent arterioles in mice after renal ischaemia-reperfusion injury.
Q HuangQ WangS ZhangS JiangL ZhaoL YuMichael HultströmA PatzakL LiC S WilcoxE Y LaiPublished in: Acta physiologica (Oxford, England) (2016)
Renal IRI in mice selectively impairs afferent arteriolar responses to Ang II because of H2 O2 accumulation that is caused by a reduced catalase activity. This could serve to buffer the effect of Ang II after IRI and may be a protective mechanism.
Keyphrases
- angiotensin ii
- hydrogen peroxide
- angiotensin converting enzyme
- vascular smooth muscle cells
- high fat diet induced
- nitric oxide
- insulin resistance
- heart failure
- acute ischemic stroke
- coronary artery disease
- metabolic syndrome
- blood brain barrier
- atrial fibrillation
- percutaneous coronary intervention
- skeletal muscle