Circular RNA CRIM1 functions as a ceRNA to promote nasopharyngeal carcinoma metastasis and docetaxel chemoresistance through upregulating FOXQ1.

Xiaohong HongNa LiuYelin LiangQingmei HeXiaojing YangYuan LeiPanpan ZhangYin ZhaoShiwei HeYaqin WangJunyan LiQian LiJun MaYing-Qin Li

Published in: Molecular cancer (2020)

Our findings reveal the critical role of circCRIM1 specifically in promoting NPC metastasis and chemoresistance via a ceRNA mechanism and provide an exploitable biomarker and therapeutic target for prognosis and treatment resistance in NPC patients.

Keyphrases

end stage renal disease
long non coding rna
ejection fraction
newly diagnosed
chronic kidney disease
prognostic factors
peritoneal dialysis
squamous cell carcinoma
genome wide
single cell
patient reported outcomes
dna methylation
locally advanced
cancer stem cells