Metabolic Activity of Visceral Adipose Tissue Is Associated with Metastatic Status of Lymph Nodes in Endometrial Cancer: A 18 F-FDG PET/CT Study.
Kisoo PahkKi Jin RyuChanmin JoungHyun Woo KwonSanghoon LeeHyuntae ParkTak KimJae Yun SongSungeun KimPublished in: International journal of environmental research and public health (2021)
Obesity contributes to increased cancer incidence and aggressiveness in patients with endometrial cancer. Inflamed metabolic activity of visceral adipose tissue (VAT) is regarded as a key underlying mechanism of adverse consequences of obesity. The aim of this study was to investigate the association between inflammatory metabolic activity of VAT evaluated by 18 F-fluorodeoxyglucose positron emission tomography/computed tomography ( 18 F-FDG PET/CT) and metastatic status of lymph nodes (LN) in patients with endometrial cancer. In total, 161 women with newly diagnosed endometrial cancer, who received preoperative 18F-FDG PET/CT, were enrolled. VAT inflammatory metabolic activity was defined as V/S ratio and measured from the maximum standardized uptake value (SUVmax) of VAT normalized to the SUVmax of subcutaneous adipose tissue (SAT). The positive LN metastasis group exhibited a significantly higher V/S ratio than the negative LN metastasis group. Systemic inflammatory surrogate markers including high sensitivity C-reactive protein, spleen SUVmax, and bone marrow SUVmax were also higher in the LN metastasis group than in the negative LN metastasis group, showing significant correlations with V/S ratio. In multivariate logistic regression analysis, V/S ratio was independently associated with LN metastasis. V/S ratio is independently associated with the LN metastasis status in patients with endometrial cancer. This finding could be useful as a potential surrogate marker of obesity-induced VAT inflammation associated with tumor aggressiveness.
Keyphrases
- endometrial cancer
- insulin resistance
- positron emission tomography
- adipose tissue
- computed tomography
- lymph node
- metabolic syndrome
- oxidative stress
- bone marrow
- type diabetes
- weight loss
- small cell lung cancer
- high fat diet induced
- high fat diet
- newly diagnosed
- squamous cell carcinoma
- weight gain
- magnetic resonance imaging
- mesenchymal stem cells
- skeletal muscle
- emergency department
- patients undergoing
- risk assessment
- risk factors
- physical activity
- early stage
- image quality
- young adults
- papillary thyroid
- endothelial cells
- contrast enhanced
- rectal cancer
- data analysis
- childhood cancer