Oxidative and endoplasmic reticulum stress in respiratory disease.
Alice C-H ChenLucy BurrMichael A McGuckinPublished in: Clinical & translational immunology (2018)
Oxidative stress and endoplasmic reticulum (ER) stress are related states that can occur in cells as part of normal physiology but occur frequently in diseases involving inflammation. In this article, we review recent findings relating to the role of oxidative and ER stress in the pathophysiology of acute and chronic nonmalignant diseases of the lung, including infections, cystic fibrosis, idiopathic pulmonary fibrosis and asthma. We also explore the potential of drugs targeting oxidative and ER stress pathways to alleviate disease.
Keyphrases
- induced apoptosis
- endoplasmic reticulum stress
- oxidative stress
- idiopathic pulmonary fibrosis
- endoplasmic reticulum
- cystic fibrosis
- drug induced
- signaling pathway
- lung function
- liver failure
- chronic obstructive pulmonary disease
- dna damage
- pseudomonas aeruginosa
- diabetic rats
- ischemia reperfusion injury
- respiratory failure
- cancer therapy
- cell proliferation
- intensive care unit
- risk assessment
- rheumatoid arthritis
- hepatitis b virus
- pi k akt