Warfarin dose requirement in patients having severe thrombosis or thrombophilia.

Tuukka Antero HelinLotta Joutsi-KorhonenHeidi AsmundelaMikko NiemiArto OrpanaRiitta Lassila

Published in: British journal of clinical pharmacology (2019)

In severe thrombosis and/or thrombophilia, variation in thrombin generation and pharmacodynamics influences warfarin response. Pharmacogenetic dosing algorithms seem to underestimate dose requirement.

Keyphrases

pulmonary embolism
atrial fibrillation
venous thromboembolism
newly diagnosed
ejection fraction
machine learning
early onset
direct oral anticoagulants
prognostic factors
oral anticoagulants