Amitriptyline prevents CPT-11-induced early-onset diarrhea and colonic apoptosis without reducing overall gastrointestinal damage in a rat model of mucositis.

K FakihaJ K CollerR M LoganR J GibsonJoanne M Bowen

Published in: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer (2018)

Prophylactic amitriptyline was able to inhibit early intestinal damage in this rat model of CPT-11-induced GIM, but exacerbated late-onset injury. These findings do not support use of amitriptyline as an approach for mitigation of GIM in this setting.

Keyphrases

early onset
late onset
oxidative stress
diabetic rats
high glucose
climate change
endoplasmic reticulum stress
radiation therapy
cell death
cell proliferation
cell cycle arrest
signaling pathway
clostridium difficile