SB431542 partially inhibits high glucose-induced EMT by restoring mitochondrial homeostasis in RPE cells.

Jingjing CaoMingfei JiaoZhenyu KouFeifei HanLijie Dong

Published in: Cell communication and signaling : CCS (2024)

SB431542 improved EMT in RPE cells by maintaining mitochondrial homeostasis via the ERK1/2 and GSK3β/β-catenin pathways. Video Abstract SB431542 inhibits EMT in RPE cells under high glucose conditions.

Keyphrases

high glucose
induced apoptosis
endothelial cells
epithelial mesenchymal transition
cell cycle arrest
signaling pathway
oxidative stress
pi k akt
cell proliferation
endoplasmic reticulum stress
cell death
stress induced