Activation of dopamine receptor D1 promotes osteogenic differentiation and reduces glucocorticoid-induced bone loss by upregulating the ERK1/2 signaling pathway.
Jie ZhuChengcheng FengWeicheng ZhangZhidong WangMengdan ZhongWenkai TangZhifang WangHaiwei ShiZhengyu YinJiandong ShiYu HuangLong XiaoDechun GengZhirong WangPublished in: Molecular medicine (Cambridge, Mass.) (2022)
Activation of D1R promotes osteogenic differentiation and reduces Dex-induced bone loss by activating the ERK1/2 pathway. Hence, D1R could serve as a potential therapeutic target for glucocorticoid-induced osteoporosis.