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Design and simulation of a microfluidics-based artificial glomerular ultrafiltration unit to reduce cell-induced fouling.

Bhagyashree SaudKoushik GuhaJacopo IannacciSergei SelishchevPratim SenguptaArindam Dutta
Published in: Artificial organs (2024)
Given that it is not dependent on the functionality of grown cells, the proposed device is anticipated to have a longer lifespan due to its non-cell-based design. The device's cost can be reduced by avoiding cell cultivation inside of it. It can be integrated as a glomerular functional unit with other units of kidney model to build a fully developed artificial kidney.
Keyphrases
  • single cell
  • cell therapy
  • high glucose
  • stem cells
  • oxidative stress
  • endothelial cells
  • diabetic nephropathy
  • bone marrow
  • endoplasmic reticulum stress