Model-based in silico analysis of the PI3K/Akt pathway: the elucidation of cross-talk between diabetes and breast cancer.

Sammia RehmanAyesha ObaidAnam NazAmjad AliShahzina KanwalJamil Ahmad

Published in: PeerJ (2018)

The PN model verified that alterations in O-GlcNAc signaling affect both insulin resistance and breast cancer. Moreover, the combination therapy for breast cancer patients consisting of anti-diabetic drugs such as Metformin along with OGT inhibitors, for example BZX, can produce better treatment regimens.

Keyphrases

type diabetes
insulin resistance
cardiovascular disease
glycemic control
adipose tissue
metabolic syndrome
high fat diet
polycystic ovary syndrome
wound healing
high fat diet induced
molecular dynamics simulations