HLA-B27 positivity in a large miscegenated population of 5,389,143 healthy blood marrow donors in Brazil.

Gustavo Gomes ResendeCarla Gonçalves Schahin SaadDanielli Cristina Muniz de OliveiraJulio Silvio de Sousa Bueno FilhoPercival Degrava Sampaio-BarrosMarcelo de Medeiros Pinheiro

Published in: Advances in rheumatology (London, England) (2023)

Our findings provide the first Brazilian national prevalence for HLA-B27 in 4.35%. There is a gradient gene positivity from North to South, suggesting that the genetic background related to the miscegenation due to colonization, slavery, and some later waves of immigration together with internal migratory flows, could explain our findings.

Keyphrases

genome wide
copy number
quality improvement
tertiary care
dna methylation
gene expression
genome wide identification
drug induced