Chlorogenic acid protects PC12 cells against corticosterone-induced neurotoxicity related to inhibition of autophagy and apoptosis.

Xiaowen ShiNian ZhouJieyi ChengXunlong ShiHai HuangMing-Mei ZhouHaiyan Zhu

Published in: BMC pharmacology & toxicology (2019)

Our results provide a new molecular mechanism for the treatment of CORT-induced neurotoxicity by CGA, and suggest CGA may be a potential substance which is can alleviate depression.

Keyphrases

diabetic rats
high glucose
oxidative stress
endoplasmic reticulum stress
cell death
drug induced
depressive symptoms
endothelial cells
signaling pathway
risk assessment
combination therapy