Simultaneous Quantitation of Paracetamol and Lornoxicam in the Presence of Five Related Substances and Toxic Impurities by a Selective HPLC-DAD Method.

Amira F El-Yazbi Karin M GuirguisMona M BedairTarek S Belal

Published in: Journal of AOAC International (2022)

To the best of our knowledge, this is the first impurity profiling assay method for this combination in the presence of five of their toxic related substances and impurities. Taking into consideration that at least two of the studied impurities (AMP and APD) are actually reported degradation products for the main drugs, the suggested method can be considered stability-indicating as well.

Keyphrases

ms ms
simultaneous determination
mass spectrometry
drinking water
high performance liquid chromatography
liquid chromatography tandem mass spectrometry
tandem mass spectrometry
high throughput
single cell
protein kinase
high resolution