Lyophilized powder of mesenchymal stem cell supernatant attenuates acute lung injury through the IL-6-p-STAT3-p63-JAG2 pathway.

Wenjun PengMeijia ChangYuanyuan WuWensi ZhuLin TongGe ZhangQin WangJie LiuXiaoping ZhuTingting ChengYijia LiXi ChenDong WengSanhong LiuHongwei ZhangYao SuJian ZhouHuayin LiYuanlin Song

Published in: Stem cell research & therapy (2021)

MSC SLP ameliorated ALI by activating p63 and promoting p63+ cell proliferation and the repair of damaged epithelial cells. The findings of this study also shed insight into ALI pathogenesis and imply that MSC SLP shows considerable therapeutic promise for treating ALI and ARDS.

Keyphrases

cell proliferation
mesenchymal stem cells
lipopolysaccharide induced
signaling pathway
bone marrow
lps induced
cell cycle
stem cells
big data
inflammatory response
intensive care unit
pi k akt
machine learning
artificial intelligence
deep learning