Molecular Subclasses of Clear Cell Ovarian Carcinoma and Their Impact on Disease Behavior and Outcomes.
Kelly L BoltonDenise ChenRosario I CoronaZhuxuan FuRajmohan MuraliMartin KoebelYanis TaziJulie M CunninghamIrenaeus C C ChanBrian J WileyLea A MoukarzelStacey J WinhamSebastian M ArmasuJenny LesterEsther ElishaevAngela LaslavicCatherine J KennedyAnna PiskorzMagdalena SekowskaAlison H BrandYoke-Eng ChiewPaul David Peter PharoahKevin Meyer EliasRonny DrapkinMichael ChurchmanCharlie GourleyAnna De FazioBeth Y KarlanJames D BrentonJorge S Reis-FilhoMichael S AnglesioDavid HuntsmanSimon GaytherJason KonnerFrancesmary ModugnoKate LawrensonEllen L GoodeElli PapaemmanuilPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)
Our study suggests that CCOC consists of two distinct molecular subclasses with distinct clinical presentation and outcomes, with potential relevance to both traditional and experimental therapy responsiveness. See related commentary by Lheureux, p. 4838.