Silver-Catalyzed Oxidative C(sp3 )-P Bond Formation through C-C and P-H Bond Cleavage.

Lili LiWenbin HuangLijin ChenJiaxing Dong Xuebing Ma Yungui Peng

Published in: Angewandte Chemie (International ed. in English) (2017)

The silver-catalyzed oxidative C(sp3 )-H/P-H cross-coupling of 1,3-dicarbonyl compounds with H-phosphonates, followed by a chemo- and regioselective C(sp3 )-C(CO) bond-cleavage step, provided heavily functionalized β-ketophosphonates. This novel method based on a readily available reaction system exhibits wide scope, high functional-group tolerance, and exclusive selectivity.

Keyphrases

gold nanoparticles
room temperature
dna binding
silver nanoparticles
photodynamic therapy
transition metal
radiation therapy
transcription factor
drug delivery
mass spectrometry
rectal cancer
locally advanced