Novel formulation of parthenolide-loaded liposome coated with chitosan and evaluation of its potential anticancer effects in vitro.
Parisa Karimian EnsafMohammad Taghi GoodarziMasoud Homayouni TabriziAli NeamatiSamira Sadat HosseinyzadehPublished in: Molecular biology reports (2024)
In a dose-dependent manner, PN-chitosome exhibited anticancer properties that were more cytotoxic against cancer cells than normal cells. Moreover, the formulation activated both the apoptosis pathway and cytotoxic genes in real-time qPCR experiments. According to the cytotoxicity and activating apoptosis of the prepared modified particle, PN-chitosome may be helpful in the treatment of cancer.
Keyphrases
- cell cycle arrest
- drug delivery
- cell death
- endoplasmic reticulum stress
- induced apoptosis
- pi k akt
- oxidative stress
- signaling pathway
- papillary thyroid
- cancer therapy
- wound healing
- squamous cell
- genome wide
- squamous cell carcinoma
- combination therapy
- lymph node metastasis
- replacement therapy
- dna methylation
- hyaluronic acid
- young adults