Efficacy of Metformin Treatment with Respect to Weight Reduction in Children and Adults with Obesity: A Systematic Review.

Y E Lentferink Catherijne A J Knibbe Marja M J van der Vorst

Published in: Drugs (2019)

The effects of metformin on weight/BMI vary, with smaller reductions in children than in adults. This could be because of differences in adherence, daily dosage, and insulin status. Metformin significantly reduced the progression toward T2DM in adults. Therefore, metformin should be considered as a treatment for obesity and its related complications.

Keyphrases

weight loss
weight gain
type diabetes
body mass index
insulin resistance
physical activity
metabolic syndrome
young adults
glycemic control
risk factors
adipose tissue
skeletal muscle
combination therapy