Influence of age on pharmacokinetics of capecitabine and its metabolites in older adults with cancer: a pilot study.

Mohsen ShafieiPeter GalettisPhilip BealeStephanie E ReuterJennifer H MartinAndrew J McLachlanPrunella Blinman

Published in: Cancer chemotherapy and pharmacology (2023)

5-FU exposure was significantly increased in older adults compared to younger adults receiving equivalent doses of capecitabine, and is a possible cause for increased toxicity in older adults.

Keyphrases

physical activity
phase ii study
locally advanced
papillary thyroid
metastatic breast cancer
phase iii
metastatic colorectal cancer
ms ms
oxidative stress
squamous cell
middle aged
clinical trial
squamous cell carcinoma
rectal cancer
radiation therapy
open label
young adults
study protocol
childhood cancer