Alternative splicing of HSPA12A pre-RNA by SRSF11 contributes to metastasis potential of colorectal cancer.

Yao-Jie PanFu-Chun HuoMeng-Jie KangBo-Wen LiuMeng-Di WuDong-Sheng Pei

Published in: Clinical and translational medicine (2022)

SRSF11 exerts pro-metastatic effects in CRC by inhibiting the AS of HSPA12A pre-RNA. Our findings point to SRSF11-regulated HSPA12A splicing as a novel relationship between SRSF11-regulated splicing and CRC metastasis and suggest a PAK5/SRSF11/HSPA12A axis as a potential therapeutic target and prognostic biomarker in CRC.

Keyphrases

heat shock protein
transcription factor
squamous cell carcinoma
small cell lung cancer
human health
anti inflammatory
risk assessment