Synthesis and preclinical evaluation of novel 18 F-vancomycin-based tracers for the detection of bacterial infections using positron emission tomography.
G B SpoelstraS N BlokL Reali NazarioL NoordY FuN A SimethF F A IJpmaM van OostenJ M van DijlB L FeringaW SzymanskiP H ElsingaPublished in: European journal of nuclear medicine and molecular imaging (2024)
F]PQ-VE1-vancomycin for image-guided detection of Gram-positive bacteria. Our study paves the way towards real-time bacteria-targeted diagnosis of soft tissue and implant-associated infections that are oftentimes caused by Gram-positive bacteria, even after prophylactic treatment with vancomycin.